Construction of the school begun on March 16, 1985. During this time, Kindergarten to Fourth Grade classes were temporarily held at La Salle Green Hills as construction was delayed because of the costs and logistics that were involved in building a school on a mountain.
Classes were transferred to the Antipolo campus on January 13, 1986 and were housed in two buildings. A third building was completed in the summer of 1987, with a fourth one completed in 1989. The school's St. Benilde Multi-purpose Hall was finished in 1991, while the high school and laboratory-library buildings were completed in 1994.
The Tertiary Education Unit was launched on year 1998, BS in Education and BS in Accountancy were the pioneer courses that time.
In 2006, La Salle College became part of De La Salle Philippines, Inc.